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Is thyroxine and levothyroxine the same thing? Levothyroxine Preparations Levothyroxine is a synthetic (man-made) version of thyroxine, or T4, the main hormone that is made and released by your thyroid gland. Levothyroxine is prescribed for people with an underactive thyroid, a condition known as hypothyroidism. Losing weight with thyroid disease can be a struggle. ot8tx77q4w