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How do people get ulcers? The most common causes of peptic ulcers are infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) (Advil, Aleve, others). Stress and spicy foods do not cause peptic ulcers. However, they can make your symptoms worse.
Will ulcers go away on their own? Some peptic ulcers heal on their own. But if you don't treat them, the ulcers tend to come back. Prescription drugs called cytoprotective agents can help protect the lining of the stomach or small intestine so the ulcer can heal.
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